Novel Engineered AAV Variants Demonstrate Superior Blood-Brain Barrier Penetration and Safety in Non-Human Primates
Zhenhua Wang, Hao Li, Xianggang Xu, Z. P Sun, Rui He, Linlin Zhang, Mengmeng Yu, Shengwen Wang, Can Hu, Lei Liu, Lele Ren, Yanling Xu, Tongqian Xiao, Daoyuan Li, Bo Sun, , Zhenming An
The paper develops novel AAV variants with improved BBB penetration and safety in NHPs, showing higher brain transduction and reduced organ toxicity.
bioRxiv · Apr 1, 2026 · PreprintNeuroscience