Author

Rui He

Qilu Pharmaceutical Co., Ltd. (China)ORCID 0000-0002-9263-5913Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rui He2 papers · Jilin University

Biology Disciplines

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Bioengineering· 2 Neuroscience· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:non-human primate· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:plant (other)· 1

Frequent Co-Authors

Hao LiiD· 4 shared Mengmeng YuiD· 4 shared Shengwen Wang· 4 shared Xianggang Xu· 4 shared Youguang Luo· 4 shared Zhenhua WangiD· 4 shared Zhenming An· 4 shared Bo Sun· 3 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

Hao LiORCID

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Author profile →

5 papers

Recent·Most cited

Novel Muscle-Tropic AAV Capsids with Dramatically Enhanced Transduction and Safety Profiles in Non-Human Primates

Youguang Luo, Linlin Zhang, Zhenhua Wang, Hao Li, Rui He, Xiaofei Lv, Xianggang Xu, Shengwen Wang, Zhen Sun, Mengmeng Yu, Qun Zhang, Peilu Zhao, Long Wang, Bo Sun, Daoyuan Li, Zhenming An

The paper engineers AAV capsids with improved muscle transduction and reduced off-target distribution in non-human primates using the REACH platform.

bioRxiv · May 26, 2026 · PreprintBioengineering

Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human Primates

Zhenhua Wang, Hao Li, Zhen Sun, Xianggang Xu, Qun Zhang, Peilu Zhao, Long Wang, Tongqian Xiao, Mengmeng Yu, Shengwen Wang, Rui He, Can Hu, Daoyuan Li, Bo Sun, Linlin Zhang, , Zhenming An

The paper identifies AAV capsid variants with improved intravitreal transduction and safety in non-human primates.

bioRxiv · Apr 24, 2026 · PreprintBioengineering

Novel Engineered AAV Variants Demonstrate Superior Blood-Brain Barrier Penetration and Safety in Non-Human Primates

Zhenhua Wang, Hao Li, Xianggang Xu, Z. P Sun, Rui He, Linlin Zhang, Mengmeng Yu, Shengwen Wang, Can Hu, Lei Liu, Lele Ren, Yanling Xu, Tongqian Xiao, Daoyuan Li, Bo Sun, , Zhenming An

The paper develops novel AAV variants with improved BBB penetration and safety in NHPs, showing higher brain transduction and reduced organ toxicity.

bioRxiv · Apr 1, 2026 · PreprintNeuroscience

LRP6-Guided Engineering of AAV9 Variants with Enhanced Blood-Brain Barrier Penetration and Reduced Liver Tropism in Non-Human Primates

Zhenhua Wang, Xianggang Xu, Zhen Sun, Hao Li, Rui He, Yanling Xu, Mengmeng Yu, Shengwen Wang, Can Hu, Lei Liu, Lele Ren, Li Zhang, Tongqian Xiao, Youguang Luo, Zhenming An

This study engineers AAV9 variants guided by LRP6 to enhance BBB penetration and reduce liver tropism in non-human primates.

bioRxiv · Mar 18, 2026 · PreprintNeuroscience

Molecular Arms Race: Tannin Biosynthesis and Laccase-Based Detoxification in the Aphid-Gall System

Qin Lu, Juan Liu, Weiwei Wang, Xin Zhang, Rui He, Gang Cao, Kirst King‐Jones, Hang Chen

This study investigates tannin biosynthesis in plants and detoxification mechanisms in aphids, revealing key genes and enzymes involved in both processes and their evolutionary implications.

bioRxiv · Dec 16, 2025 · PreprintEvolutionary Biology