Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas
L. Wasim, S. W. T. Chu, B. Sale, L. Pickard, S. Leonard, L. Zhang, H. Tolarova, Z. S. Tean, N. Engels, D. P. Calado, K. Tarte, J. Okosun, F. Forconi, P. Tolar
This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.
bioRxiv · Apr 12, 2024 · PreprintImmunology