S. Leonard

Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntingtons disease

This study evaluates blocking huntingtin membrane binding as a therapeutic strategy for HD, identifying two compounds that alleviate HD phenotypes in C. elegans.

Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas

This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.

Lymphoma B cells remodel bone marrow stromal cell organization and function to induce a supportive cancer-associated fibroblast network

This study identifies how lymphoma B cells alter bone marrow stromal cell organization and function, creating a supportive cancer-associated fibroblast network in follicular lymphoma.

NGFR regulates germinal center B-cell activation and negative selection

This study shows that NGFR regulates germinal center B-cell activation and negative selection by maintaining GC structure and function, affecting antibody production and immune tolerance.

The Pathfinder plasmid toolkit for genetically engineering newly isolated bacteria enables the study of Drosophila-colonizing Orbaceae

The paper introduces the Pathfinder plasmid toolkit to test genetic part compatibility in newly isolated bacteria, demonstrating its use in engineering Orbaceae strains to study their colonization of Drosophila gut.

Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma

The paper identifies interactions between tumor-associated macrophages and blood endothelial cells in DLBCL using single-cell profiling and confirms their role in an immunosuppressive microenvironment linked to poor prognosis.

Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development

The paper investigates how BCL2 oncogene deregulation in mouse models affects B-cell fate and pre-malignant development through two genetic constructs.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

RNA chaperones Hfq and ProQ play a key role in the virulence of the plant pathogenic bacterium Dickeya dadantii

This study shows that RNA chaperones Hfq and ProQ regulate virulence in Dickeya dadantii by affecting mRNA levels of virulence factors.

Mass cytometry and artificial intelligence define CD169 as a specific marker of SARS-CoV2-induced acute respiratory distress syndrome

The paper identifies a specific immune signature in COVID-19-associated ARDS using mass cytometry and AI, showing it differs from other ARDS causes and is linked to adverse ICU outcomes.