D. P. Calado

Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas

This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.

Epi-microRNA mediated metabolic reprogramming ensures affinity maturation

This study identifies miR-155's role in metabolic reprogramming of GC-B cells to support affinity maturation under hypoxic conditions.

Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1+ GC B cell positive selection

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

N-myristoyltransferase inhibition causes mitochondrial dysfunction and cell death in MYC-deregulated cancers through post-transcriptional failure in complex I synthesis.

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

Genetic timestamping of plasma cells in vivo reveals homeostatic population turnover

The paper develops a genetic tool for in vivo manipulation of plasma cells and shows their homeostatic turnover through timestamping.