Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts
Z.-D. Ge, S. L. Baumgardt, J. Fang, X. Fu, Y. Liu, Z. Xia, M. Zhao, L. Chen, R. Mishra, M. Gunasekaran, P. Saha, J. M. Forbess, Z. J. Bosnjak, A. K. S. Camara, J. Kersten, , S. Kaushal
This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.
bioRxiv · Feb 21, 2023 · PreprintPharmacology & Toxicology