R. Mishra

Intronic miR-6741-3p is involved in oral squamous cell carcinoma pathogenesis by targeting the oncogene SRSF3

This study identifies miR-6741-3p as a tumor suppressor in oral squamous cell carcinoma by targeting SRSF3, showing its potential as a therapeutic target.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

Inhibition of hyperactive cyclin dependent kinase 5/p25 is protective in the 6-hydroxydopamine model of Parkinson's disease

This study shows that inhibiting hyperactive CDK5/p25 protects dopamine neurons in a Parkinson's disease model.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Effect of earthworms in removal and fate of Antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARG) during clinical laboratory wastewater treatment by vermifiltration

This study investigates how earthworms and vermifiltration affect the removal of antibiotic resistant bacteria and genes in clinical wastewater, showing significant pathogen reduction and shifts in resistance patterns.

Design, Performance Evaluation and Investigation of the Dynamic Mechanisms of Earthworm-Microorganisms interactions for wastewater treatment through Vermifiltration technology

This study investigates earthworm-microorganism interactions in vermifiltration for wastewater treatment, finding that earthworm gut microbes dominate and that predation regulates microbial biomass and activity.

Imperative role of particulate matter in innate immunity during RNA virus infection

This study investigates how particulate matter PM10 affects RNA virus infection in lung cells, finding it enhances pathogenicity and alters host immune and metabolic responses.

Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

This study identifies miR-30e as a master regulator of innate immune responses during HBV infection and SLE, showing its role in modulating immune pathways and therapeutic potential.

A comprehensive role of Toll-like receptors (TLRs) in diabetic wound healing

This study investigates the role of TLRs in diabetic wound healing and finds that TLR2 and TLR4 inhibition improves healing in db/db mice.

Drosophila Hox genes induce melanised pseudo-tumours when misexpressed in hemocytes

This study shows that misexpression of Drosophila Hox genes in hemocytes leads to melanised pseudo-tumours and lethality, suggesting a role in hematopoietic dysregulation and leukemia.