The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract
Y. Shi, L. Shuai, Z. Wen, C. Wang, Y. Yan, Z. Jiao, F. Guo, Z. F. Fu, H. Chen, Z.-G. Bu, G. Peng
This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.
bioRxiv · Nov 12, 2020Microbiology