Author

L. Shuai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

C. Wang· 3 shared Z. Wen· 2 shared C. Peng· 1 shared C. Schindewolf· 1 shared C.-I. Wu· 1 shared F. Guo· 1 shared F.-J. Zhang· 1 shared F.-L. Liu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

C. Wang

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Author profile →

3 papers

Recent·Most cited

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

N. Hou, L. Shuai, L. Zhang, X. Xie, K. Tang, Y. Zhu, Y. Yu, W. Zhang, Q. Tan, G. Zhong, Z. Wen, C. Wang, X. He, H. Huo, H. Gao, , Q. Hu

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

bioRxiv · Aug 10, 2022 · PreprintMicrobiology

Homo-harringtonine (HHT) - A highly effective drug against coronaviruses and the potential for large-scale clinical applications

H.-J. Wen, P. Lin, G.-X. Zhong, Z.-C. Xu, L. Shuai, Z.-Y. Wen, C. Wang, X. Cao, W.-B. He, J. Feng, Q.-C. Cai, H.-J. Ma, S.-J. Wu, G.-D. Wang, X.-M. Lyu, , C.-I. Wu

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

bioRxiv · Apr 16, 2021 · PreprintMicrobiology

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

Y. Shi, L. Shuai, Z. Wen, C. Wang, Y. Yan, Z. Jiao, F. Guo, Z. F. Fu, H. Chen, Z.-G. Bu, G. Peng

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

bioRxiv · Nov 12, 2020Microbiology