F. Guo

Modelling mental disorders in zebrafish. Neurexins severely modulate anxiety, social behaviours and aggression.

This study generates zebrafish neurexin gene knockouts and identifies paralog-specific behavioral changes linked to anxiety, social behavior, and aggression, mirroring human psychiatric disorders.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Optically active, paper-based scaffolds for 3D cardiac tissue engineering

This paper presents a paper-based scaffold with gold nanorods and quantum dots for optical modulation of cardiac tissue in vitro, offering a high-resolution alternative to electrode-based methods.

Cryo-EM structures of the tubulin cofactors reveal the molecular basis for the biogenesis of alpha/beta-tubulin

The paper determines cryo-EM structures of tubulin cofactors bound to β-tubulin, revealing a vise-like mechanism for GTP-hydrolysis dependent α/β-tubulin biogenesis.

The role of m6A methyltransferase WTAP in inflammatory response of atherosclerosis through NF-κB/NLRP3 mediated pyroptosis

This study shows that WTAP promotes LPS-induced pyroptosis and inflammation in endothelial cells by enhancing NF-κB p50 function and facilitating its interaction with NLRP3.

Single-cell RNA-seq analysis profiling characterizes differences in cell composition and physiology between normal tissue, treatment-naive, and cisplatin-treated ovarian cancer

Dendritic cell-derived lncRNA in patients with acute coronary syndrome

This study examines lncRNA expression in monocyte-derived dendritic cells (moDC) across different ACS subtypes, identifying CCL15-CCL14 as a differentially expressed lncRNA that modulates moDC function.

Democratizing access to microfluidics: Rapid prototyping of open microchannels with low-cost LCD 3D printers

This paper compares LCD and DLP 3D printers for microfluidic fabrication, finding LCD printers are cheaper with comparable accuracy to more expensive DLP printers.

Thermoplasmonic modulation of cardiomyocytes activity with local temperature read-out

This paper develops a light-based method to modulate cardiomyocyte beating rate using near-infrared plasmonic heating and measures local temperature changes with silica-coated quantum dots.

Opposing implications of co-evolutionary lineages and traits of gut microbiome on human health status

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling

The paper introduces a method to label and profile cell-cell interactions with high sensitivity and spatial-temporal resolution using a bioorthogonal photocatalytic quinone methide decaging strategy.

Brain Organoid Computing for Artificial Intelligence

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

Expanding the diversity of Accumulibacter with a novel type and deciphering the transcriptional and morphological features among co-occurring strains

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

(Z, Z, Z)-3,6,9-nonadecadiene, a potential inhibitor of sex pheromone of Ectropis grisescens Warren (Lepidoptera: Geometridae): electroantennogram test, wind tunnel, and in silico study

Engineering human spinal microphysiological systems to model opioid-induced tolerance

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

Acrylamide Induces Protein Aggregation in CNS through Suppression of FoxO1-mediated Autophagy.

This study shows acrylamide induces proteotoxic stress in CNS by suppressing FoxO1-mediated autophagy, leading to protein aggregation and neurodegeneration.

Molecular dynamics study of phospholipid membrane electroporation induced by bipolar pulses with different intervals

This study uses molecular dynamics simulations to analyze how different intervals between bipolar pulses affect phospholipid membrane electroporation, identifying three states and their dynamics.

All atom molecular dynamics simulation of the combinedeffects of different phospholipids and cholesterolcontents on electroporation

This study uses molecular dynamics simulations to investigate how phospholipid composition and cholesterol content affect electroporation in lipid bilayers.

Simulation study of Cell Transmembrane Potential and Electroporation Induced by Time-Varying Magnetic Fields

This study simulates transmembrane potential and electroporation caused by time-varying magnetic fields, showing that nanosecond pulses are more effective than sub-microsecond pulses for membrane electroporation.

Starvation Induces Diverse Autophagic Response in Cardiomyocytes and Noncardiomyocytes.

This study shows that cardiomyocytes and noncardiomyocytes respond differently to starvation, with cardiomyocytes showing unstable autophagic activity and greater vulnerability to nutrient deprivation.

A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment

A metabolically engineered bacterium produces indole to modulate macrophages and Tregs, reducing autoimmune arthritis by altering the pro-inflammatory microenvironment.

Understanding immune-driven brain aging by human brain organoid microphysiological analysis platform

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

Espalier: Efficient tree reconciliation and ARG reconstruction using maximum agreement forests

This paper introduces a method to reconcile discordant phylogenetic trees and reconstruct ancestral recombination graphs (ARGs) using maximum agreement forests, demonstrating its accuracy and efficiency in analyzing viral genomes.

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis

The paper analyzes co-mutations across multiple cancer types to identify cooperating mechanisms in tumorigenesis and their clinical implications.

The SARS-CoV-2 nucleocapsid protein preferentially binds long and structured RNAs

This study investigates how SARS-CoV-2 nucleocapsid protein binds RNA, finding it preferentially interacts with structured and long RNAs, and proposes a mechanism linking packaging to RNA recognition.

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

Rice LEAFY COTYLEDON1 hinders photosynthesis in the embryo development to promote seed dormancy

This study shows that OsLEC1 inhibits photosynthesis in rice embryos to promote seed dormancy by regulating hormonal pathways and gene networks.

Host poly(A) polymerases PAPD5 and PAPD7 provide two layers of protection that ensure the integrity and stability of hepatitis B virus RNA

This study investigates how PAPD5 and PAPD7 stabilize HBV RNA and shows that PAPD5 is dominant in protecting the poly(A) tail, while PAPD7 acts as a backup mechanism.