Author

Zachi Horn

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Assay:protein structure· 1

Frequent Co-Authors

Mary E. HatteniD· 4 shared Hourinaz BehestiiD· 3 shared Court HulliD· 2 shared Amanda Liljenström· 1 shared Åsa Tellgren‐Roth· 1 shared Gunnar von HEIJNEiD· 1 shared Hilda Amalia PasolliiD· 1 shared IngMarie NilssoniD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Mary E. HattenORCID

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Author profile →

4 papers

Recent·Most cited

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Michalina Hanzel, Kayla Fernando, Susan E. Maloney, Zachi Horn, Shiaoching Gong, Kärt Mätlik, Jiajia Zhao, Hilda Amalia Pasolli, Søren Heissel, Joseph D. Dougherty, Court Hull, Mary E. Hatten

This study shows that Astn2 knockout mice display ASD-like behaviors and altered cerebellar circuit properties, including changes in synaptic transmission and glial volume.

Proceedings of the National Academy of Sciences · Aug 16, 2024Peer-reviewedNeuroscience

Murine astrotactins 1 and 2 have similar membrane topology and mature via endoproteolytic cleavage catalyzed by signal peptidase

Patricia Lara, Åsa Tellgren‐Roth, Hourinaz Behesti, Zachi Horn, Nina Schiller, Karl Enquist, Malin Cammenberg, Amanda Liljenström, Mary E. Hatten, Gunnar von HEIJNE, IngMarie Nilsson

This study maps the membrane topology and maturation mechanism of murine Astn1 and Astn2, showing they mature via endoproteolytic cleavage by signal peptidase.

Journal of Biological Chemistry · Jan 29, 2019Peer-reviewedNeuroscience

N-Cadherin Provides a Cis and Trans Ligand for Astrotactin that Functions in Glial-Guided Neuronal Migration

Zachi Horn, Hourinaz Behesti, Mary E. Hatten

This study shows that ASTN1 binds N-cadherin (CDH2) in cis and trans, forming a bridge complex that supports glial-guided neuronal migration.

Proceedings of the National Academy of Sciences · Sep 27, 2018Peer-reviewedDevelopmental Biology

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins

Hourinaz Behesti, Taylor R. Fore, Peter Wu, Zachi Horn, Mary L. O’Connor Leppert, Court Hull, Mary E. Hatten

This study shows ASTN2 modulates synaptic activity by regulating surface protein expression through endocytosis and degradation in Purkinje cells.

Proceedings of the National Academy of Sciences · Sep 21, 2018Peer-reviewedNeuroscience