Court Hull

Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons

The paper demonstrates that networks of molecular layer interneurons use ephaptic signals to control Purkinje cell firing timing in vivo.

Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning

This study investigates how cerebellar climbing fiber activity relates to reward prediction errors in learning, showing that CF signals share characteristics with reinforcement learning rPEs and influence motor behavior.

Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells

The paper investigates how climbing fiber inputs selectively excite disinhibitory interneurons to enhance dendritic calcium signaling in Purkinje cells, supporting cerebellar learning.

A deep-learning strategy to identify cell types across species from high-density extracellular recordings

This paper develops a deep-learning classifier to identify cell types from extracellular recordings across species with over 95% accuracy.

Cerebellar climbing fibers signal flexible, rapidly adapting reward predictions

This study investigates how cerebellar climbing fibers respond to reward-predictive stimuli and finds they generate flexible, context-sensitive reward prediction signals.

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

This study shows that Astn2 knockout mice display ASD-like behaviors and altered cerebellar circuit properties, including changes in synaptic transmission and glial volume.

Cerebellar circuits for disinhibition and synchronous inhibition

The paper identifies two MLI subtypes with distinct connectivity and functional roles in cerebellar circuits, showing how disinhibition gates cerebellar-dependent learning.

Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

The paper uses snRNA-seq to study Purkinje cells in SCA7 mice, revealing zebrin-II subtype loss as a key feature of polyglutamine ataxias.

Thousandfold Cell-Specific Pharmacology of Neurotransmission

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

Local synaptic inhibition mediates cerebellar pattern separation necessary for learned sensorimotor associations

This study shows that local synaptic inhibition in the cerebellar granule cell layer sparsens sensory responses and enables pattern separation, crucial for sensorimotor learning in mice.

Acetylcholine modulates cerebellar granule cell spiking by regulating the balance of synaptic excitation and inhibition

This study shows acetylcholine modulates cerebellar granule cell spiking by altering the balance of excitation and inhibition through effects on Golgi cells and mossy fibers.

Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

The paper investigates how climbing fibers in the lateral cerebellum signal reward prediction during classical conditioning, showing distinct responses in three regions that guide reward-based learning.

Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition

This study shows serotonin increases tonic inhibition of cerebellar granule cells by modulating Golgi cells, reducing spike probability without altering spike timing.

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins

This study shows ASTN2 modulates synaptic activity by regulating surface protein expression through endocytosis and degradation in Purkinje cells.

Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions

This study investigates cerebellar climbing fiber activity in mice during motor learning, finding that CFs are preferentially driven by task parameters predicting reward outcomes, suggesting a role in learned sensorimotor predictions.