Hourinaz Behesti

The paper develops a protocol to generate human cerebellar granule cells from pluripotent stem cells and identifies molecular differences in their development compared to mice.

This study compares gene expression in human and mouse Purkinje cells using transcriptomics, identifying shared and distinct genetic pathways and a novel human marker gene.

This study maps the membrane topology and maturation mechanism of murine Astn1 and Astn2, showing they mature via endoproteolytic cleavage by signal peptidase.

This study shows that ASTN1 binds N-cadherin (CDH2) in cis and trans, forming a bridge complex that supports glial-guided neuronal migration.

This study shows ASTN2 modulates synaptic activity by regulating surface protein expression through endocytosis and degradation in Purkinje cells.