Binfeng Lu

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium

This study shows dedifferentiation-derived oncogenic stem cells sustain intestinal tumorigenesis more effectively than mutant stem cells, with aberrant Notch signaling and metabolic plasticity contributing to tumor growth.

Causal Modeling Reveals Cell-Cell Communication Dynamics in the Tumor Microenvironment During Anti-PD-1 Therapy in Breast Cancer Patients

This study uses single-cell RNA-seq data to analyze cell-cell communication changes in breast cancer patients during anti-PD-1 therapy, identifying key pathways and potential therapeutic targets.

Inferring Personalized Cell-Cell Communication Networks in Colorectal Cancer with Individualized Causal Discovery

This paper develops a framework to infer individualized cell-cell communication networks in colorectal cancer using causal discovery methods applied to single-cell RNA-seq data.

Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancer

The paper uses single-cell data to identify gene expression modules regulated by cell-cell communication in colorectal cancer and validates findings with spatial transcriptomics.

Current transcriptome database and biomarker discovery for immunotherapy by immune checkpoint blockade

This paper reviews biomarkers for immune checkpoint blockade therapy, compares existing databases, and introduces IOhub, a web portal for benchmarking biomarkers using bulk and single-cell transcriptome datasets.

Loss of Protein Kinase D2 Activity Protects Against Bleomycin-induced Dermal Fibrosis in Mice

This study shows that reducing PKD2 activity in mice prevents bleomycin-induced dermal fibrosis by decreasing collagen and inflammatory markers.