Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites
Antoine Sicard, Meilin Tian, Zakaria Mostefai, Sophie Shi, Cécile Cardoso, Joseph Zamith, Isabelle McCort‐Tranchepain, Cécile Charrier, Pierre Paoletti, Laétitia Mony
This study introduces Opto2B, a tool to selectively modulate GluN2B diheteromers, revealing their minor role in synaptic and extrasynaptic NMDAR pools in adult hippocampal CA1 pyramidal cells.
bioRxiv · Oct 14, 2024 · PreprintNeuroscience