Cécile Charrier

This paper identifies the human-specific gene FRMPD2B as an activity- and experience-regulated modifier of cortical connectivity, showing its role in postnatal brain development.

This study introduces Opto2B, a tool to selectively modulate GluN2B diheteromers, revealing their minor role in synaptic and extrasynaptic NMDAR pools in adult hippocampal CA1 pyramidal cells.

The paper identifies CTNND2 as an SRGAP2 effector that regulates synaptic maturation and links human evolution to synaptic neoteny.

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

The paper develops a 3D-CLEM approach to study spine ultrastructure in mouse somatosensory cortex and models its impact on synaptic inhibition.