Author

Sophie Shi

Centre National de la Recherche ScientifiqueORCID 0000-0002-7746-1695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electronic health records· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:Xenopus· 1

Frequent Co-Authors

Laurie PeveriniiD· 2 shared Pierre‐Jean CorringeriD· 2 shared Alexandre PozzaiD· 1 shared Andreas ZoumpoulakisiD· 1 shared Antoine SicardiD· 1 shared Carlos A. H. FernandesiD· 1 shared Catherine Vénien‐BryaniD· 1 shared Cécile CardosoiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Laurie PeveriniORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome.

Dania Zuniga, Andreas Zoumpoulakis, Rafael F. Veloso, Laurie Peverini, Sophie Shi, Alexandre Pozza, Valérie Kugler, Françoise Bonneté, Tahar Bouceba, Renaud Wagner, Pierre‐Jean Corringer, Carlos A. H. Fernandes, Catherine Vénien‐Bryan

This study investigates two Kir2.1 mutants linked to Andersen-Tawil syndrome, showing they impair channel function through distinct mechanisms, with C154Y causing dominant-negative effects.

The FASEB Journal · Nov 9, 2024Peer-reviewedBiophysics

Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites

Antoine Sicard, Meilin Tian, Zakaria Mostefai, Sophie Shi, Cécile Cardoso, Joseph Zamith, Isabelle McCort‐Tranchepain, Cécile Charrier, Pierre Paoletti, Laétitia Mony

This study introduces Opto2B, a tool to selectively modulate GluN2B diheteromers, revealing their minor role in synaptic and extrasynaptic NMDAR pools in adult hippocampal CA1 pyramidal cells.

bioRxiv · Oct 14, 2024 · PreprintNeuroscience

Mapping the molecular motions of 5-HT3 serotonin-gated channel by Voltage-Clamp Fluorometry

Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre‐Jean Corringer

This study uses voltage-clamp fluorometry to map conformational changes in the 5-HT3 serotonin-gated channel, linking them to electrophysiological states and agonist effects.

eLife · Dec 20, 2023Peer-reviewedMolecular Biology