Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice
Justin Jacobse, Jennifer M. Pilat, Anna Brooke Harris, Aaron Kwag, Zaryab Aziz, Channing Chi, Sam Schaefer, M. Diana Neely, Matthew A. Buendia, Andrew P Pahnke, Christopher S. Williams, Wentao Deng, M. Kay Washington, Jeffrey C. Rathmell, Charles Robb Flynn, , Yash A. Choksi
This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.
bioRxiv · Sep 9, 2025 · PreprintImmunology