Author

Wentao Deng

Vanderbilt University Medical CenterORCID 0009-0004-9903-9702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Jeffrey C. RathmelliD· 2 shared Aaron Kwag· 1 shared Alan J. SimmonsiD· 1 shared Andrew P PahnkeiD· 1 shared Anna Brooke Harris· 1 shared Brian C. GriebiD· 1 shared Channing ChiiD· 1 shared Charles Robb FlynniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Jeffrey C. RathmellORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice

Justin Jacobse, Jennifer M. Pilat, Anna Brooke Harris, Aaron Kwag, Zaryab Aziz, Channing Chi, Sam Schaefer, M. Diana Neely, Matthew A. Buendia, Andrew P Pahnke, Christopher S. Williams, Wentao Deng, M. Kay Washington, Jeffrey C. Rathmell, Charles Robb Flynn, , Yash A. Choksi

This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.

bioRxiv · Sep 9, 2025 · PreprintImmunology

Scalable single-cell pooled CRISPR screens with conventional knockout vector libraries

Mirazul Islam, Yilin Yang, Alan J. Simmons, Yanwen Xu, Emilie L. Fisher, Wentao Deng, Brian C. Grieb, Paola Molina, Christian R. de Caestecker, Marisol A Ramirez-Solano, Qi Liu, William P. Tansey, Ian G. Macara, Jeffrey C. Rathmell, Robert J. Coffey, Ken S. Lau

This paper introduces NSC-seq, a direct sgRNA capture method for single-cell CRISPR screens using standard knockout libraries, and characterizes sgRNA expression in three whole-genome libraries.

bioRxiv · Feb 1, 2024 · PreprintGenomics