The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

bioRxiv · Mar 10, 2026 · PreprintImmunology

Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice

Justin Jacobse, Jennifer M. Pilat, Anna Brooke Harris, Aaron Kwag, Zaryab Aziz, Channing Chi, Sam Schaefer, M. Diana Neely, Matthew A. Buendia, Andrew P Pahnke, Christopher S. Williams, Wentao Deng, M. Kay Washington, Jeffrey C. Rathmell, Charles Robb Flynn, , Yash A. Choksi

This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.

bioRxiv · Sep 9, 2025 · PreprintImmunology

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn's Disease

Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank L. Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, , Qi Liu

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

Nature Communications · Aug 22, 2024Peer-reviewedBioinformatics