Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and Neurodegeneration
Yuval Rabuah, Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik, Ekaterina Eremenko, Shai Kaluski, Monica Einav, Ekaterina E. Khrameeva, Debra Toiber
This paper develops a reversible SIRT6 deficiency model to study brain aging and neurodegeneration, finding transcriptomic changes resembling aging and Alzheimer's disease.
bioRxiv · Feb 17, 2026 · PreprintMolecular Biology