Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein Synthesis.
Miguel Portillo, Ekaterina Eremenko, Shai Kaluski, Alfredo García-Venzor, Lior Onn, Daniel Stein, Zeev Slobodnik, Adam Zaretsky, Uwe Ueberham, Monica Einav, Martina K. Brückner, Thomas Arendt, Debra Toiber
The paper shows that Tau hyper-acetylation at residue 174 increases its nuclear presence, leading to changes in gene expression and contributing to Alzheimer's disease pathology.
Cell Reports · Apr 1, 2021Peer-reviewedMolecular Biology