Uwe Ueberham

The paper examines somatic copy number variant (CNV) frequencies in neurons from Alzheimer's disease patients and healthy controls using low-coverage single-cell whole-genome sequencing, finding slightly higher CNV frequencies in AD patients but no statistically significant differences.

The paper shows that Tau hyper-acetylation at residue 174 increases its nuclear presence, leading to changes in gene expression and contributing to Alzheimer's disease pathology.