Thomas Arendt

The paper examines somatic copy number variant (CNV) frequencies in neurons from Alzheimer's disease patients and healthy controls using low-coverage single-cell whole-genome sequencing, finding slightly higher CNV frequencies in AD patients but no statistically significant differences.

This study shows that tau and α-synuclein regulate microtubule organization and transport in neuronal dendrites, with tau deficiency increasing dendritic complexity and transport efficiency.

The paper links MRI relaxation rate in substantia nigra to iron concentration in dopaminergic neurons, enabling early Parkinson's disease detection.

The paper shows that Tau hyper-acetylation at residue 174 increases its nuclear presence, leading to changes in gene expression and contributing to Alzheimer's disease pathology.