Nanoscale PI(4,5)P2 partitioning driven by FGF2 oligomerization triggers membrane pore formation
Alessandra Griffo, Daniel Beyer, Jaime Fernandez-Sobaberas, Melanie König, Zeynep Kilcan, Manpreet Kaur, Eleonora Germana Margheritis, Katia Cosentino, Petra Riegerová, Martin Hof, Radek Šachl, Walter Nickel, Fabio Lolicato
This paper shows FGF2 oligomerization drives PI(4,5)P2 partitioning and membrane pore formation, enabling FGF2 translocation across the plasma membrane.
bioRxiv · Sep 11, 2025 · PreprintBiochemistry