Zhe Fu

Synora: vector-based boundary detection for spatial omics

Synora identifies tumor-stroma boundaries in spatial omics data using cell coordinates and tumor/non-tumor labels, achieving robust boundary detection across datasets and modalities.

Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a TLR9 dependent manner

This paper shows that tarloxotinib, a hypoxia-activated prodrug, reduces tumor hypoxia and enhances immune checkpoint inhibitor efficacy through TLR9-dependent mechanisms in multiple tumor models.