Emily Liu

Learning Genetic Perturbation Effects with Variational Causal Inference

This paper introduces SCCVAE, a hybrid model combining mechanistic causal models with deep learning to predict and simulate genetic perturbation responses in single-cell data.

Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a TLR9 dependent manner

This paper shows that tarloxotinib, a hypoxia-activated prodrug, reduces tumor hypoxia and enhances immune checkpoint inhibitor efficacy through TLR9-dependent mechanisms in multiple tumor models.

Morphological principles of neuronal mitochondria

The paper analyzes mitochondrial morphology in mouse cerebellum neurons using 3D TEM data to quantify structural features that influence metabolic output.