Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD synthesis
Mercedes Rivera, Renee B. Chang, Colin M. Lewis, Romi Hadary, Julia M. Kovalski, Krista G. Freeman, Zhen-Yu J Sun, Rotem Sorek, Graham F. Hatfull, Philip J. Kranzusch
This study identifies RyDEP as an enzyme that degrades 2'cADPR and 3'cADPR immune signals, inactivating bacterial defense and restoring NAD+.
bioRxiv · May 29, 2026 · PreprintMicrobiology