Author

Krista G. Freeman

University of PittsburghORCID 0000-0002-2944-5076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Graham F. HatfulliD· 3 shared Andrew P. VanDemarkiD· 1 shared Antoni LuqueiD· 1 shared Colin Brown· 1 shared Colin M. Lewis· 1 shared Danny JiangiD· 1 shared Deborah Jacobs‐SeraiD· 1 shared Jennifer M. PodgorskiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

Graham F. HatfullORCID

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3 papers

Recent·Most cited

Mycobacteriophage Adephagia gp48 inhibits essential host cell wall biosynthesis enzyme mannose-1-phosphate guanylyltransferase

Michael J. Lauer, Krista G. Freeman, Danny Jiang, Jindanuch Maneekul, Andrew P. VanDemark, Graham F. Hatfull

This paper identifies gp48, a mycobacteriophage protein that inhibits the host enzyme Mpg, essential for cell wall biosynthesis, by disrupting its dimer formation.

bioRxiv · Sep 17, 2026 · PreprintMicrobiology

Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD synthesis

Mercedes Rivera, Renee B. Chang, Colin M. Lewis, Romi Hadary, Julia M. Kovalski, Krista G. Freeman, Zhen-Yu J Sun, Rotem Sorek, Graham F. Hatfull, Philip J. Kranzusch

This study identifies RyDEP as an enzyme that degrades 2'cADPR and 3'cADPR immune signals, inactivating bacterial defense and restoring NAD+.

bioRxiv · May 29, 2026 · PreprintMicrobiology

A novel stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Jennifer M. Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs‐Sera, Krista G. Freeman, Colin Brown, Graham F. Hatfull, Antoni Luque, Simon J. White

The paper identifies a novel capsid stabilization mechanism in bacteriophages that allows larger genomes to be packaged without changing capsid size, offering insights for gene delivery system engineering.

bioRxiv · Nov 3, 2023 · PreprintMolecular Biology