Faf2/Ubx2 potentiates p97/Cdc48 segregase activity via functional priming and reinforcement of the UT3 domain in Ufd1
Y T Ren, Qingyun Zheng, Yujuan Duan, Zhengyang Xu, Qian Qu, Yicheng Weng, S. P. Cui, Yuanyun Yu, Man Pan, Lei Liu
This study shows Faf2/Ubx2 enhances p97/Cdc48 segregase activity by remodeling its substrate recognition module and priming its motor engagement, enabling efficient substrate processing.
bioRxiv · Feb 27, 2026 · PreprintBiochemistry