Lei Liu

This study identifies a hierarchical anchoring-gating mechanism in the MSL complex that ensures specific H4K16 acetylation and reveals its role in chromatin accessibility and transcription.

This study shows Faf2/Ubx2 enhances p97/Cdc48 segregase activity by remodeling its substrate recognition module and priming its motor engagement, enabling efficient substrate processing.

The paper determines cryo-EM structures of IMiDs in full CRL4CRBN complexes, revealing a cryptic interfacial pocket that enhances IMiD efficacy and neosubstrate specificity.