Man Pan

This study shows Faf2/Ubx2 enhances p97/Cdc48 segregase activity by remodeling its substrate recognition module and priming its motor engagement, enabling efficient substrate processing.

This paper develops a conformation-specific antibody, K27-IgG, to detect K27-linked polyubiquitin and identifies DNAJB1 as a reader and UBE2Q1 as a writer for this ubiquitin chain type.

The paper determines cryo-EM structures of IMiDs in full CRL4CRBN complexes, revealing a cryptic interfacial pocket that enhances IMiD efficacy and neosubstrate specificity.

The paper identifies a unique mechanism by which ASXL1 K351 monoubiquitination enhances PR-DUB activity through structural stabilization, enabling efficient H2AK119Ub deubiquitination.

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.