A ZBP1 isoform blocks ZBP1-mediated cell death
Zhi-Yu Cai, Puqi Wu, Hao Liang, Yu-Ze Xie, Bo-Xin Zhang, Cai-Ling He, Cong-Rong Yang, Hongda Li, Wei Mo, Zhang-Hua Yang
This paper identifies a ZBP1 isoform (ZBP1-S) that suppresses ZBP1-mediated cell death by competing for Z-NA binding, revealing alternative splicing as a regulatory mechanism for inflammation.
bioRxiv · Feb 2, 2024Immunology