Author

Bo-Xin Zhang

Sir Run Run Shaw Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Wei MoiD· 3 shared Zhang-Hua Yang· 3 shared Zhiyu CaiiD· 3 shared Baizhou LiiD· 2 shared Huan-Feng Ye· 2 shared Jia Huang· 2 shared Lei Wu· 2 shared Pu Cheng· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Wei MoORCID

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Author profile →

3 papers

Recent·Most cited

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhiyu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, , Wei Mo

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

Zhang-Hua Yang, Bo-Xin Zhang, Huan-Feng Ye, Liang Shi, Rui Gong, Zhiyu Cai, Qiang Chen, Lei Wu, Jia Huang, Le Zhang, Huipeng Jiao, Pinglong Xu, Qinjie Weng, Jie Zhang, Jinheng Pan, , Wei Mo

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

Vita · Jan 1, 2026Peer-reviewedCell Biology

ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death

Zhang-Hua Yang, Puqi Wu, Bo-Xin Zhang, Congrong Yang, Jia Huang, Lei Wu, Shaoyu Guo, Yuenan Zhou, Yuanhui Mao, Yafei Yin, Xiurong Wu, Pu Cheng, Baizhou Li, Rongbin Zhou, Han‐Ming Shen, , Wei Mo

This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.

Molecular Cell · Apr 22, 2025Peer-reviewedCell Biology