Hongda Li

This paper identifies a ZBP1 isoform (ZBP1-S) that suppresses ZBP1-mediated cell death by competing for Z-NA binding, revealing alternative splicing as a regulatory mechanism for inflammation.

This study shows that microglial Piezo1 senses Aβ fibril stiffness, influencing AD pathology by affecting phagocytosis and plaque compaction.