ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response
Liying Guan, Tong Zhang, Zhigao Zhan, Yingchun Wang, Xun Huang, Mei Ding
The paper shows that ERGIC2 and ERGIC3 modulate UPR signaling by interacting with BiP, revealing their role in stress adaptation beyond cargo transport.
bioRxiv · Dec 17, 2025 · PreprintCell Biology