Xun Huang

A missense mutation in FBXL3 links circadian regulation to out-of-season estrus in sheep

This study identifies a missense mutation in FBXL3 linked to seasonal breeding in sheep, showing it affects circadian rhythms and estrus patterns.

Box H/ACA snoRNP regulates lipid storage through insulin signaling pathway in Drosophila melanogaster

The paper identifies GAR1 as a key regulator of lipid storage and insulin signaling in Drosophila, showing its role in alternative splicing and metabolic homeostasis.

ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response

The paper shows that ERGIC2 and ERGIC3 modulate UPR signaling by interacting with BiP, revealing their role in stress adaptation beyond cargo transport.

A partner switch from CDS2 to RAB1A redirects MBOAT7 to inhibit DGAT2-mediated lipid droplet growth

The paper shows MBOAT7 redistributes to ER-LD contacts via RAB1 to inhibit DGAT2-mediated lipid droplet growth in response to CDS2 disruption.

Membrane rupture and independent extension of sister membranes drive cytokinesis in C. elegans embryos

This study reveals that cytokinesis in C. elegans embryos occurs through membrane rupture and independent extension of sister membranes, challenging the classical model of continuous membrane invagination.

Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger

The paper identifies nhr-114 and spin-4 as suppressors of seip-1 embryonic lethality in C. elegans, showing that reducing phosphatidylcholine synthesis suppresses lethality but worsens lipid droplet abnormalities.

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons

The paper investigates how chronic ER stress is alleviated in C. elegans neurons through the p38-Ire1-Xbp1 pathway and insulin-associated autophagy.

The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in C. elegans

The paper shows that UBR-1 in C. elegans regulates glutamate levels, affecting motor neuron activity and locomotion.