Liying Guan

The paper shows that ERGIC2 and ERGIC3 modulate UPR signaling by interacting with BiP, revealing their role in stress adaptation beyond cargo transport.

This study investigates how RUNX1 isoforms B and C regulate RUNX1 and its target genes in megakaryocytes and platelets, and links these regulatory patterns to clinical cardiovascular events.

The paper introduces an in situ cut-and-paste genome editing method using CRISPR/Cas9 or Cas12a, demonstrating its ability to insert, substitute, and delete sequences in mammalian genomes.

The paper investigates how chronic ER stress is alleviated in C. elegans neurons through the p38-Ire1-Xbp1 pathway and insulin-associated autophagy.