Microglial pruning of extinction-ensemble synapses preserves fear memory
Yongling Wang, Yue Cao, Taohui Liu, Tian-Tian Shi, Yaoguang Zhao, Zhihao Jin, Xiaoyu Yang, S Y Wang, Jia-Ze Ruan, Fan Zhang, Wei-Ke Li, Yang He, Sheng-Jie Lin, Wenying Xu, Xin Yi, , Tian‐Le Xu
The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.
bioRxiv · May 7, 2026 · PreprintNeuroscience