Tian‐Le Xu

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

This study shows that remimazolam in the thalamic nucleus reuniens disrupts fear extinction by altering hippocamposeptal circuits.

This study identifies a specific LEC-vCA1 pathway that uses low gamma-band oscillations to facilitate fear extinction and shows its therapeutic potential through DBS and tACS in a PTSD mouse model.

This study uses multi-omics analysis to identify the serotonin transporter as a potential therapeutic target for essential tremor in a mouse model.

This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.

This study identifies phosphatidylserine (PS) as a critical lipid for ASIC1a synaptic targeting and function through electrostatic interactions.

The paper shows that forgetting of extinction memory involves a dynamic shift in the connectivity of engram circuits between the mPFC, BLA, and vHPC.