Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming
Jasim Khan, Sarmad Mehmood, Fuad Al Abir, Miao Wei, Suhail Muzaffar, Suha Mohiuddin, Shanrun Liu, Mohammad Waseem, Juheb Akhter, Zhipeng Liu, David K. Crossman, Masakazu Kamata, Jake Y. Chen, Chander Raman, Craig Elmets, , Lin Jin
This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.
bioRxiv · Sep 16, 2026 · PreprintBioengineering