Mohammad Waseem

Human-specific remodeling of an endogenous retrovirus shapes structural diversity at acrocentric nucleolar organizer regions

The paper reconstructs the evolution of a human-specific endogenous retrovirus, K111, showing its role in shaping structural diversity at acrocentric nucleolar organizer regions through parental transmission and remodeling.

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

Centromeric α-satellite DNA is a hotspot of genotoxic damage, incomplete repair, and cytoplasmic mislocalization

The paper shows that centromeric α-satellite DNA is prone to genotoxic damage, incomplete repair, and cytoplasmic mislocalization, leading to chromosome instability and chromatin antigen exposure.

Bleomycin induces active-centromere damage and cytoplasmic mislocalization of centromeric chromatin in fibroblasts

This study shows bleomycin causes centromere damage and chromatin mislocalization in fibroblasts, linking it to systemic sclerosis features.