Liquid liquid phase separation of the intrinsically disordered protein JPT2compartmentalizes components of NAADP-evoked Ca2+ signaling
Sushil Kumar, Gihan S. Gunaratne, Jasmine Cornish, Kirsten M Silvey, Qianru Mu, Zhong Guan, Gabriella T. Heller, James T. Slama, Sandip Patel, Jonathan S. Marchant
This study shows JPT2, an intrinsically disordered NAADP-binding protein, undergoes liquid-liquid phase separation, forming condensates that recruit components involved in NAADP-evoked Ca2+ signaling.
bioRxiv · Jan 11, 2026 · PreprintBiophysics