Sandip Patel

This study shows JPT2, an intrinsically disordered NAADP-binding protein, undergoes liquid-liquid phase separation, forming condensates that recruit components involved in NAADP-evoked Ca2+ signaling.

The paper identifies a splice variant-dependent localization of PMCA2 to lysosomes and links it to neurodegenerative diseases.

The paper identifies AIP as a regulator that links mTORC1 activation with catabolic metabolism during neonatal development, ensuring metabolic adaptation and survival.

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.