Author

Zhuo Guan

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2

Frequent Co-Authors

J. Troy LittletoniD· 3 shared Elizabeth A. Brija· 1 shared Maria BykhovskaiaiD· 1 shared Mónica C. Quiñones-Frías· 1 shared Suresh Kumar JettiiD· 1 shared Yulia AkbergenovaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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3 shared papersNeuroscience

J. Troy LittletonORCID

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3 papers

Recent·Most cited

Disease-causing mutations in Synaptotagmin can act via dominant-negative, gain-of-function or haploinsufficient mechanisms

Zhuo Guan, Maria Bykhovskaia, J. Troy Littleton

The paper investigates how disease-causing mutations in Synaptotagmin affect synaptic transmission through different mechanisms in a Drosophila model.

bioRxiv · Mar 18, 2026 · PreprintNeuroscience

Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release

Elizabeth A. Brija, Zhuo Guan, Suresh Kumar Jetti, J. Troy Littleton

The paper shows stochastic RNA editing of Complexin in single neurons generates diverse protein variants that regulate neurotransmitter release by altering subcellular localization and clamping properties.

Cell Reports · Sep 1, 2023Peer-reviewedNeuroscience

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner

Zhuo Guan, Mónica C. Quiñones-Frías, Yulia Akbergenova, J. Troy Littleton

This study shows Drosophila Syt7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner, challenging the two Ca2+ sensor model of neurotransmitter release.

eLife · Apr 28, 2020Peer-reviewedNeuroscience