Yulia Akbergenova

Active zone maturation state controls synaptic output and release mode and is differentially regulated by neuronal activity

The paper shows that active zone maturation state determines synaptic release mode and strength, and that neuronal activity regulates AZ number and size during development.

Molecular Logic of Synaptic Diversity Between Drosophila Tonic and Phasic Motoneurons

The paper identifies molecular pathways underlying synaptic diversity between Drosophila tonic and phasic motoneurons through single-cell RNA profiling and genetic analysis.

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

This study shows that Perlecan is essential for maintaining axonal and synaptic stability in Drosophila motoneurons, with its loss causing axonal breakage and synaptic retraction.

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

The paper identifies Tomosyn as a regulator of synaptic release properties and homeostatic plasticity in Drosophila motoneurons.

Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in Drosophila

This study investigates how tonic and phasic motoneurons in Drosophila respond to activity changes or ablation, showing distinct structural and functional plasticity.

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner

This study shows Drosophila Syt7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner, challenging the two Ca2+ sensor model of neurotransmitter release.

Examining molecular determinants underlying heterogeneity of synaptic release probability using optical quantal imaging

The paper examines the molecular determinants of synaptic release probability heterogeneity using optical quantal imaging in Drosophila neuromuscular junctions.