J. Troy Littleton

The paper investigates how disease-causing mutations in Synaptotagmin affect synaptic transmission through different mechanisms in a Drosophila model.

The paper identifies RNA editing sites in Drosophila glutamatergic motoneurons, revealing stochastic editing patterns and cell-type specific edits that may influence synaptic function.

The paper shows that active zone maturation state determines synaptic release mode and strength, and that neuronal activity regulates AZ number and size during development.

The paper shows stochastic RNA editing of Complexin in single neurons generates diverse protein variants that regulate neurotransmitter release by altering subcellular localization and clamping properties.

The paper identifies molecular pathways underlying synaptic diversity between Drosophila tonic and phasic motoneurons through single-cell RNA profiling and genetic analysis.

This study shows that Perlecan is essential for maintaining axonal and synaptic stability in Drosophila motoneurons, with its loss causing axonal breakage and synaptic retraction.

The paper investigates how voltage-gated Ca2+ channel abundance at Drosophila active zones is regulated through delivery, turnover, and interactions with BRP and 2{delta}.

The paper identifies Tomosyn as a regulator of synaptic release properties and homeostatic plasticity in Drosophila motoneurons.

The paper shows disruption of Ca2+ oscillations in Drosophila perineurial glia leads to seizure-like behavior without affecting BBB structure.

This study investigates how tonic and phasic motoneurons in Drosophila respond to activity changes or ablation, showing distinct structural and functional plasticity.

This study shows Drosophila Syt7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner, challenging the two Ca2+ sensor model of neurotransmitter release.

This study shows that glial Ca2+ signaling regulates neuronal excitability through K+ buffering via calcineurin-dependent endocytosis and K2P channel expression in Drosophila.

The paper examines the molecular determinants of synaptic release probability heterogeneity using optical quantal imaging in Drosophila neuromuscular junctions.