Yixin Zhang

KDRD: assessing discovery replicability based on summary association statistics from a single study

KDRD estimates replicability of associations using summary statistics from a single study, showing moderate to high replicability for 33 of 45 brain-related traits in proteomics analyses.

Pair-complete structural gating enables Pareto optimization of de novo cyclic peptides with preserved binding geometry and improved developability

This paper introduces RF-PepTune, a method that improves cyclic peptide design by preserving binding geometry while optimizing multiple properties, achieving higher success rates in structural and functional criteria.

Cardiac Reprogramming with Drug Resistance Alleviates Doxorubicin-induced Cardiotoxicity in Mice and Pigs

This paper introduces a strategy called TopCare to reduce doxorubicin-induced cardiotoxicity by temporarily increasing P-gp expression in cardiomyocytes, showing improved survival and cardiac function in mice and pigs.

Merits and challenges of plasma proteomics on association replicability

The paper assesses the replicability of plasma proteomics associations with phenotypes using UK Biobank data, finding high replicability for cognitive and mental health traits and developing a framework to predict replicability in future panels.

Self-Reactive B Cells in Artery Tertiary Lymphoid Organs Encode Pathogenic High Affinity Autoantibody in Atherosclerosis

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

A Model-Based Clustering via Mixture of Bayesian Hierarchical Models with Covariate Adjustment for Detecting Differentially Expressed Genes from Paired Design

This paper introduces a Bayesian hierarchical mixture model with covariate adjustment to detect differentially expressed genes in paired design whole-genome data, showing improved performance over existing methods.