Author

Ziyue Zou

University of California, San FranciscoPrimary ORCID profile (0009-0004-5516-6099 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Ziyue ZouiD1 paper · University of California San Francisco

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aashish ManglikiD· 1 shared Balázs R. VargaiD· 1 shared Christian B. MacdonaldiD· 1 shared Daniel D. RichmaniD· 1 shared Eve J. FineiD· 1 shared Harold PimenteliD· 1 shared J. N. K. RaoiD· 1 shared James S. FraseriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Aashish ManglikORCID

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Author profile →

1 paper

Recent·Most cited

Distinct activation mechanisms underlie ligand efficacy at a GPCR

Marybeth Howard, Eve J. Fine, Karthik Srinivasan, Daniel D. Richman, Jerome Freudenberg, Zara Y. Weinberg, J. N. K. Rao, Ziyue Zou, Christian B. Macdonald, Patrick Rockefeller Grimes, Balázs R. Varga, James S. Fraser, Mark von Zastrow, Susruta Majumdar, Harold Pimentel, , Willow Coyote‐Maestas

This study uses deep mutational pharmacology to show how different residues in the -opioid receptor determine the efficacy of opioids by shaping distinct activation mechanisms.

bioRxiv · Oct 18, 2026 · PreprintBiophysics