Author
Washington University in St. LouisORCID 0000-0002-2931-3823Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Marybeth Howard, Eve J. Fine, Karthik Srinivasan…·Willow Coyote‐Maestas
This study uses deep mutational pharmacology to show how different residues in the -opioid receptor determine the efficacy of opioids by shaping distinct activation mechanisms.
Vikram Dalal, Vipin Ashok Rangari, Samuel Eriksson Lidbrink…·Wayland W.L. Cheng
This study identifies molecular determinants of ligand recognition and efficacy in TRPM3's voltage sensor-like domain using a combination of structural and functional analyses.
Evan S. O’Brien, Junzheng Wang, Parthasaradhireddy Tanguturi…·Brian K. Kobilka
This study discovers μ-opioid receptor positive allosteric modulators (PAMs) and investigates their dynamic mechanism of action to enhance opioid agonist activity while reducing side effects.
Michael J. Robertson, Arnab Modak, Makaía M. Papasergi-Scott…·Georgios Skiniotis
The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.
M. Bram Kuijer, Camryn J. Fulton, Talia L. Albert…·Bryan L. Roth
The paper examines how sodium ions differentially modulate agonist-induced conformational changes and signaling at μ and κ opioid receptors, revealing opposing effects between the two receptor types.
Xi-Ping Huang, Tao Che, Thomas Mangano…·Bryan L Roth
This study investigates the pharmacological profiles of W-18 and W-15, finding no significant opioid activity or other psychoactive drug target interactions.